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2nd Edition

The Chemic Components of Tobacco and Tobacco Smoke

Copyright Year 2013

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Authored past two longtime researchers in tobacco science, The Chemic Components of Tobacco and Tobacco Fume, Second Edition chronicles the progress made from late 2008 through 2011 past scientists in the field of tobacco scientific discipline. The book examines the isolation and label of each component. It explores developments in pertinent analytical technology and results of experimental studies on biological activity, toxicity, and tumorigenicity, including the inhibition of agin biological activity of one specific tobacco smoke component past another tobacco fume component.

Adding to the progress reported in the First Edition, the comprehensive 2nd Edition provides well-nigh 7,000 references on well-nigh ix,600 components. The authors discuss the controversies over the extrapolation of the biological effect of a specific component administered individually by one route versus its biological consequence when the component is in a highly complex mixture and is administered by a different road. They as well cite studies in which cigarette design technologies were developed to control the per-cigarette mainstream smoke yield of Federal Merchandise Commission–defined tar and one or more specific tobacco smoke components of concern.

New in the Second Edition:

  • Approximately ane,000 newly reported components have been inserted and several dozen duplicates have been deleted from various tables and from the Alphabetical Index
  • Improved and sharper chemical structures
  • Insertion of new pertinent references for the components in each of the major chapter tables devoted to a particular functional component
  • Updated Index organized by the CAS Registry Number listing of the components
  • Updated discussions in the Introduction and at the beginning of each affiliate
  • A searchable companion CD-ROM containing the 350-page alphabetical Component Index

Authors Alan Rodgman and Thomas A. Perfetti were jointly awarded the 2010 CORESTA (Cooperative Eye for Scientific Research Relative to Tobacco) Prize for their extensive work on documenting the vast literature on the chemical composition of tobacco and tobacco smoke in their original edition.

Tabular array of Contents

Hydrocarbons
Alkanes
Alkenes and Alkynes
Alicyclic Hydrocarbons
Monocyclic Aromatic Hydrocarbons
Polycyclic Effluvious Hydrocarbons
Summary
Alcohols and Phytosterols
Alcohols
Phytosterols
Aldehydes and Ketones
Assertion of Aldehydes and Ketones as Ciliastatic Tobacco Smoke Components
Ciliastasis Studies with Cigarette Fume Condensate Fractions
Ciliastasis Studies with Individual Cigarette Mainstream Smoke Components
Nose Inhalation of Ecology Tobacco Smoke vs. Oral cavity Inhalation of Mainstream Smoke
Carboxylic Acids
Carboxylic Acids
Amino Acids and Related Compounds
Esters
Lactones
Anhydrides
Carbohydrates and Their Derivatives
Phenols and Quinones
Phenols
Quinones
Ethers
Overall Summary of Oxygen-Containing Components of Tobacco and/or Smoke: Chapters two through x
Nitriles
Acyclic Amines
Amides
Imides
Due north-Nitrosamines
Volatile NNAs
Nonvolatile NNAs
Tobacco-Specific NNAs
Northward-Nitrosamino Acids
Tobacco-Specific NNAs: An Exception among the Major MSS Toxicants
Direct Transfer of TSNAs from Tobacco vs. Their Germination during the Smoking Process
Infrequently Studied Tobacco and/or Smoke Secondary Amines and Their Due north-Nitroamines
Flue Curing and TSNAs
Nitroalkanes, Nitroarenes, and Nitrophenols
Nitrogen Heterocyclic Components
Monocyclic Four and V-Membered Northward-Containing Ring Compounds
Monocyclic Six-Membered N-Containing Ring Compounds
Lactams
Oxazoles and Oxazines
Aza-Arenes
N-Heterocyclic Amines
Miscellaneous Components
Sulfur-Containing Components
Halogenated Components
Stock-still and Variable Gases
Belittling Methods
Metallic and Nonmetallic Elements, Isotopes, Ions, and Salts
Elements, Isotopes, and Ions in Plants
Methods for the Detection and Identification of Metals, Ions, and Isotopes in Tobacco and Tobacco Smoke
The Transference of Elements, Isotopes, and Ions from Tobacco to Tobacco Smoke
Summary
Pesticides and Growth Regulators
Synthetic Pesticides and Plant Growth Regulator Residues on Tobacco
Naturally Occurring Institute Growth Regulators and Pesticides in Tobacco
Transfer Rates of Pesticides and Constitute Growth Regulators to MSS
Decomposition Products of Agrochemicals in MSS
Methods for Analyses of Pesticides and Institute Growth Regulators
Residues of Synthetic Pesticides and Plant Growth Regulators Identified in Tobacco and Tobacco Fume
Genes, Nucleotides, and Enzymes
General Discussion of Genetics
Tobacco Genetics
Genes, Nucleotides, and Enzymes Identified in Tobacco
Acknowledgments
Hoffmann Analytes
Tobacco and/or Tobacco Smoke Components Used every bit Tobacco Ingredients
Acknowledgment
Pyrolysis
Private Tobacco Types
Extracts from Tobacco
Individual Tobacco Components
Tobacco Additives
Cigarette Construction Materials (Newspaper, Adhesives, etc.)
Flavoring Ingredients
Carcinogens, Tumorigens, and Mutagens vs. Anticarcinogens, Inhibitors, and Antimutagens
Carcinogens, Tumorigens, and Mutagens
Anticarcinogens, Inhibitors, and Antimutagens
Summary
Free Radicals
Introduction
Belittling Methods for Decision of Complimentary Radicals
Free Radicals in Tobacco Smoke
Historical Review of Free-Radical Research on Cigarette Smoke
Proposed Mechanism for the Generation of Gratuitous Radicals in MSS

 Summary
Bibliography
Alphabetical Component Index
Sequence of CAS Registry Numbers

Author(south)

Biography

Alan Rodgman, Thomas A. Perfetti

Reviews

Praise for the First Edition

… the real value of the book will turn out in its daily employ and it has all chances to go the standard reference book (perhaps 'The Bible') of all tobacco scientists.
—Dr. Gerhard Scherer, Editor of Beitrage zur Tabakforschung International, Bonn, Germany

I highly recommend this book equally an indispensable reference source for tobacco and fume chemists as well every bit other scientists involved in the study of tobacco and its products. The compilation of proper chemic names, common names, Chemical Abstract Service numbers (CAS No.), and structures alone are worth the purchase price.
—Charles R. Green, Ph.D., Retired Senior Principal Scientist, R. J. Reynolds Tobacco Company, Winston-Salem, North Carolina

Many congratulations on this monumental piece of work.
—Dr. Chuan Liu, Senior Scientist, Applied Research, Grouping Research & Development, British American Tobacco, Southampton, United kingdom

As a statistician I would like to forecast: There volition not be any other comprehensive work in the next 30-50 years about this topic – Rodgman – Perfetti volition be the definitive volume.
—Prof. Dr. Wolf-Dieter Heller, Karlsruhe, Federal republic of germany

as a reference text on a laboratory shelf it will prove essential and take its place alongside the other CRC publications.
—M. Cooke, Chromatographia 2010, 71